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Phrenic nerve transfer in the treatment of brachial plexus avulsion: an experimental study of nerve regeneration and muscle morphology in rats.
Umeå University, Faculty of Medicine, Integrative Medical Biology, Anatomy.
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2004 (English)In: Microsurgery, ISSN 0738-1085, E-ISSN 1098-2752, Vol. 24, no 3, 232-240 p.Article in journal (Refereed) Published
Abstract [en]

The regeneration of motor and sensory neurons and the morphological changes of the target muscle after phrenic nerve transfer were investigated in adult rats. Six months following nerve transfer, 326.0 +/- 16.31 phrenic motoneurons regenerated into musculocutaneous nerve, which is not different from the normal number of phrenic motoneurons. The regenerated motoneurons exhibited a 14% nonsignificant hypertrophy. Of the dorsal root ganglia (DRG) neurons, 255.8 +/- 45.26 regenerated, which was significantly lower than the number of normal phrenic DRG neurons. The regenerated phrenic DRG neurons showed a 24% close-to-significant atrophy. The target muscle fiber morphology changed considerably after reinnervation. The present results suggest that the phrenic nerve has very good regenerative ability in terms of its motoneurons and a relatively insufficient sensory neuronal regeneration.

Place, publisher, year, edition, pages
2004. Vol. 24, no 3, 232-240 p.
Keyword [en]
Animals, Brachial Plexus Neuropathies/*surgery, Disease Models; Animal, Female, Motor Neurons/ultrastructure, Muscle Fibers/*ultrastructure, Muscle; Skeletal/physiology/ultrastructure, Musculocutaneous Nerve/ultrastructure, Nerve Regeneration/*physiology, Nerve Transfer/*methods, Phrenic Nerve/*transplantation, Rats, Rats; Sprague-Dawley, Reference Values
Identifiers
URN: urn:nbn:se:umu:diva-12712DOI: doi:10.1002/micr.20015PubMedID: 15160383OAI: oai:DiVA.org:umu-12712DiVA: diva2:152383
Available from: 2007-12-11 Created: 2007-12-11 Last updated: 2017-12-14Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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