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Composite PHB-GGF conduit for long nerve gap repair: a long-term evaluation
Umeå University, Faculty of Medicine, Integrative Medical Biology, Anatomy. Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Hand Surgery.
2005 (English)In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, ISSN 0284-4311, Vol. 39, no 3, 129-137 p.Article in journal (Refereed) Published
Abstract [en]

Two to four cm nerve gaps in the rabbit common peroneal nerve were bridged with poly-3-hydroxybutyrate (PHB) conduits containing either glial growth factor (GGF) (PHB-GGF) or alginate matrix (PHB-ALG), and with empty PHB conduit (E-PHB). PHB-GGF significantly increased nerve regeneration up to 63 days following repair of long nerve gaps and the regeneration was sustained long term leading to motor organ reinnervation. At 120 days postoperatively, GGF addition significantly increased the quantity of Schwann cell and axonal regeneration compared to those in control conduits. In PHB-GGF conduits there were more minifascicles of myelinated fibres compared to the controls. The distal nerve of PHB-GGF and E-PHB conduits showed greater regeneration than that of PHB-ALG grafts, although all distal nerves contained fewer myelinated fibres than grafted conduits. Consistently, PHB-GGF conduits significantly reduced the muscle mass percentage loss compared to controls. In conclusion, GGF-containing conduits promoted sustained axonal regeneration and improved target muscle reinnervation.

Place, publisher, year, edition, pages
2005. Vol. 39, no 3, 129-137 p.
Keyword [en]
Alginates/administration & dosage, Animals, Axons/physiology, Glucuronic Acid/administration & dosage, Hexuronic Acids/administration & dosage, Hydroxybutyrates/*administration & dosage, Immunohistochemistry, Microscopy; Electron, Muscles/innervation, Nerve Regeneration/*drug effects/physiology, Neuregulin-1/*administration & dosage, Peroneal Nerve/*surgery, Polyesters/*administration & dosage, Rabbits, Schwann Cells/cytology, Time Factors
URN: urn:nbn:se:umu:diva-12714DOI: doi:10.1080/02844310510006295PubMedID: 16019744OAI: diva2:152385
Available from: 2007-12-11 Created: 2007-12-11 Last updated: 2009-09-19Bibliographically approved

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