Synthesis of 2-Substituted Pyridines via a Regiospecific Alkylation, Alkynylation, and Arylation of Pyridine N-Oxides
2007 (English)In: Organic Letters, Vol. 9, no 7, 1335-7 p.Article in journal (Refereed) Published
Sequential addition of Grignard reagents to pyridine N-oxides in THF at room temperature followed by treatment with acetic anhydride at 120 C afforded 2-substituted pyridines in good to high yields. Furthermore, by exchanging acetic anhydride for DMF in the second step, 2-substituted pyridine N-oxides were obtained, as intermediates suitable for addition of a second Grignard reagent for the synthesis of 2,6-disubstituted pyridines.
Place, publisher, year, edition, pages
2007. Vol. 9, no 7, 1335-7 p.
IdentifiersURN: urn:nbn:se:umu:diva-12793DOI: doi:10.1021/ol070184nOAI: oai:DiVA.org:umu-12793DiVA: diva2:152464