Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
2007 (English)In: FEBS Lett, ISSN 0014-5793, Vol. 581, no 4, 587-595 p.Article in journal (Refereed) Published
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
Place, publisher, year, edition, pages
2007. Vol. 581, no 4, 587-595 p.
Animals, Anti-Bacterial Agents/chemistry/*pharmacology, Bacterial Proteins/*antagonists & inhibitors/genetics/*secretion, Cell Proliferation/drug effects, Chlamydia Infections/*microbiology, Chlamydia trachomatis/cytology/drug effects, Chlamydophila pneumoniae/cytology/*drug effects, Dose-Response Relationship; Drug, Down-Regulation/drug effects, Epithelial Cells/cytology/drug effects/microbiology, Gene Expression Regulation; Bacterial/drug effects, Genes; Bacterial, Hela Cells, Humans, Mice, Transcription; Genetic/drug effects, Yersinia Infections, Yersinia pseudotuberculosis/*drug effects
IdentifiersURN: urn:nbn:se:umu:diva-12890DOI: doi:10.1016/j.febslet.2007.01.013PubMedID: 17257594OAI: oai:DiVA.org:umu-12890DiVA: diva2:152561