Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis
2006 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 194, no 10, 1367-1374 p.Article in journal (Refereed) Published
Relapsing-fever borreliosis caused by Borrelia duttonii is a common cause of complications of pregnancy, miscarriage, and neonatal death in sub-Saharan Africa. We established a murine model of gestational relapsing fever infection for the study of the pathological development of these complications. We demonstrate that B. duttonii infection during pregnancy results in intrauterine growth retardation, as well as placental damage and inflammation, impaired fetal circulation, and decreased maternal hemoglobin levels. We show that spirochetes frequently cross the maternal-fetal barrier, resulting in congenital infection. Furthermore, we compared the severity of infection in pregnant and nonpregnant mice and show that pregnancy has a protective effect. This model closely parallels the consequences of human gestational infection, and our results provide insight into the mechanisms behind the complications of pregnancy that have been reported in human relapsing-fever infection.
Place, publisher, year, edition, pages
2006. Vol. 194, no 10, 1367-1374 p.
Animals, Bacteremia, Borrelia, Disease Models; Animal, Disease Transmission; Vertical, Female, Fetal Diseases/*microbiology/pathology, Fetal Growth Retardation, Fetal Weight, Hemoglobins/analysis, Histocytochemistry, Mice, Mice; Inbred C3H, Placenta/*microbiology/pathology, Placental Circulation, Pregnancy, Pregnancy Complications; Infectious/microbiology/pathology, Relapsing Fever/microbiology/pathology/*transmission
Microbiology in the medical area Infectious Medicine
IdentifiersURN: urn:nbn:se:umu:diva-12901DOI: 10.1086/508425PubMedID: 17054065OAI: oai:DiVA.org:umu-12901DiVA: diva2:152572