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The etiological agent of Lyme disease, Borrelia burgdorferi, appears to contain
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bergström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bergström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bergström)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Johansson)
2004 (English)In: Journal of Bacteriology, ISSN 0021-9193, E-ISSN 1098-5530, Vol. 186, no 24, 8472-8477 p.Article in journal (Refereed) Published
Abstract [en]

Small regulatory RNAs (sRNAs) have recently been shown to be the main controllers of several regulatory pathways. The function of sRNAs depends in many cases on the RNA-binding protein Hfq, especially for sRNAs with an antisense function. In this study, the genome of Borrelia burgdorferi was subjected to different searches for sRNAs, including direct homology and comparative genomics searches and ortholog- and annotation-based search strategies. Two new sRNAs were found, one of which showed complementarity to the rpoS region, which it possibly controls by an antisense mechanism. The role of the other sRNA is unknown, although observed complementarities against particular mRNA sequences suggest an antisense mechanism. We suggest that the low level of sRNAs observed in B. burgdorferi is at least partly due to the presumed lack of both functional Hfq protein and RNase E activity.

Place, publisher, year, edition, pages
2004. Vol. 186, no 24, 8472-8477 p.
Keyword [en]
Animals, Borrelia burgdorferi/*genetics, Computational Biology/methods, Endoribonucleases, Genome; Bacterial, Genomics, Host Factor 1 Protein, Humans, Lyme Disease/*microbiology, MicroRNAs/*genetics, RNA; Bacterial/*genetics, Rabbits
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-12945PubMedID: 15576797OAI: oai:DiVA.org:umu-12945DiVA: diva2:152616
Available from: 2007-10-03 Created: 2007-10-03 Last updated: 2011-10-26Bibliographically approved

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Östberg, YngveBunikis, IgnasBergström, SvenJohansson, Jörgen
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