Bone marrow hyaluronan distribution in patients with acute myeloid leukemia.
2005 (English)In: Medical Oncology, ISSN 1357-0560, Vol. 22, no 1, 71-78 p.Article in journal (Refereed) Published
The present study investigated potential age-related changes in human muscle spindles with respect to the intrafusal fiber-type content and myosin heavy chain (MyHC) composition in biceps brachii muscle. The total number of intrafusal fibers per spindle decreased significantly with aging, due to a significant reduction in the number of nuclear chain fibers. Nuclear chain fibers in old spindles were short and some showed novel expression of MyHC α-cardiac. The expression of MyHC α-cardiac in bag1 and bag2 fibers was greatly decreased in the A region. The expression of slow MyHC was increased in nuclear bag1 fibers and that of fetal MyHC decreased in bag2 fibers whereas the patterns of distribution of the remaing MyHC isoforms were generelly not affected by aging. We conclude that aging appears to have an important impact on muscle spindle composition. These changes in muscle spindle phenotype may reflect an age-related deterioration in sensory and motor innervation and are likely to have an impact in motor control in the elderly.
Place, publisher, year, edition, pages
2005. Vol. 22, no 1, 71-78 p.
Adult, Aged, Aged; 80 and over, Bone Marrow/*chemistry, Female, Humans, Hyaluronic Acid/*analysis, Immunohistochemistry, Leukemia; Myelocytic; Acute/*metabolism, Male, Middle Aged, Reticulin/analysis
IdentifiersURN: urn:nbn:se:umu:diva-13170DOI: 10.1385/MO:22:1:071PubMedID: 15750199OAI: oai:DiVA.org:umu-13170DiVA: diva2:152841