Change search
ReferencesLink to record
Permanent link

Direct link
Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: A risk for AD?
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Show others and affiliations
2006 (English)In: Neurology, Vol. 66, 1029-1033 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly. The neural mechanisms by which these genetic variations influence behavioral performance or clinical severity are not well understood.

METHODS: The authors used diffusion tensor imaging to investigate ultrastructural properties in brain white matter to detect pathologic processes that modify tissue integrity. Sixty participants were included in the study of which 30 were homozygous for the APOE epsilon3 allele, 10 were homozygous for the APOE epsilon4 allele, and 20 had the APOE epsilon34 allele combination. All individuals were non-demented, and the groups were matched on demographic variables and cognitive performance.

RESULTS: The results showed a decline in fractional anisotropy, a marker for white matter integrity, in the posterior corpus callosum of epsilon4 carriers compared to non-carriers. Additional sites of altered white matter integrity included the medial temporal lobe.

CONCLUSIONS: Although the mechanism underlying vulnerability of white matter tracts in APOE epsilon4 carriers is still unknown, these findings suggest that increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia.

Place, publisher, year, edition, pages
2006. Vol. 66, 1029-1033 p.
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:umu:diva-13424DOI: 10.1212/01.wnl.0000204180.25361.48PubMedID: 16606914OAI: diva2:153095
Available from: 2007-02-27 Created: 2007-02-27 Last updated: 2015-12-14

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Persson, JonasLarsson, AnneAdolfsson, RolfNyberg, Lars
By organisation
Department of PsychologyRadiation PhysicsPsychiatry
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 40 hits
ReferencesLink to record
Permanent link

Direct link