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Reduced hippocampal volume in non-demented carriers fo the apolipoprotein E ε4: Relation to chronological age and recognition memory
Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, S-171 76 Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Social Sciences, Department of Psychology. (Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA)
Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, S-171 76 Stockholm, Sweden.
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2006 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 396, no 1, 23-27 p.Article in journal (Refereed) Published
Abstract [en]

Apolipoprotein E ε4 (APOE ε4) is the main known genetic risk factor for Alzheimer's disease (AD). Some previous studies have reported structural brain changes as well as cognitive deficits in non-demented APOE ε4 carriers, but the pattern of results is inconsistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition–memory performance between AD-symptom-free carriers (N = 30) and non-carriers (N = 30) of the APOE ε4 (age range: 49–79 years). We observed reduced right hippocampal volume in APOE ε4 carriers, and found that the difference was most pronounced before the age of 65. Further, the APOE ε4 carriers made significantly more false alarms in the recognition–memory test, and the number of false alarms correlated significantly with right hippocampus volume. These results indicate that relatively young individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait.

Place, publisher, year, edition, pages
2006. Vol. 396, no 1, 23-27 p.
Keyword [en]
Alzheimer's disease, APOE, MRI, Memory, Hippocampus
URN: urn:nbn:se:umu:diva-13507DOI: 10.1016/j.neulet.2005.11.070PubMedID: 16406347OAI: diva2:153178
Available from: 2006-11-06 Created: 2006-11-06 Last updated: 2011-05-17Bibliographically approved

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Larsson, AnneAdolfsson, RolfNyberg, Lars
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