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Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon 4 carriers
Department of Clinical Neuroscience, Karolinska Institute, MR Research Center, Karolinska Hospital.
Department of Clinical Neuroscience, Karolinska Institute, MR Research Center, Karolinska Hospital.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium.
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2006 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 17, no 16, 1683-1686 p.Article in journal (Refereed) Published
Abstract [en]

Apolipoprotein E-[varepsilon]4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondementedapolipoprotein E-[varepsilon]4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-[varepsilon]4 carriers, and hence likely progression to Alzheimer's disease.

Place, publisher, year, edition, pages
Oxford: Rapid Communications of Oxford , 2006. Vol. 17, no 16, 1683-1686 p.
Keyword [en]
Alzheimer's disease, apolipoprotein E, functional magnetic resonance imaging, memory, parietal cortex
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Medical and Health Sciences
Research subject
URN: urn:nbn:se:umu:diva-14021DOI: 10.1097/01.wnr.0000239954.60695.c6OAI: diva2:153692
Available from: 2007-05-21 Created: 2007-05-21 Last updated: 2015-12-14

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Persson, JonasAdolfsson, RolfNyberg, Lars
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