Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon 4 carriers
2006 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 17, no 16, 1683-1686 p.Article in journal (Refereed) Published
Apolipoprotein E-[varepsilon]4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondementedapolipoprotein E-[varepsilon]4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-[varepsilon]4 carriers, and hence likely progression to Alzheimer's disease.
Place, publisher, year, edition, pages
Oxford: Rapid Communications of Oxford , 2006. Vol. 17, no 16, 1683-1686 p.
Alzheimer's disease, apolipoprotein E, functional magnetic resonance imaging, memory, parietal cortex
Medical and Health Sciences
Research subject Medicine
IdentifiersURN: urn:nbn:se:umu:diva-14021DOI: 10.1097/01.wnr.0000239954.60695.c6OAI: oai:DiVA.org:umu-14021DiVA: diva2:153692