Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis
2006 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 65, no 6, 816-819 p.Article in journal (Refereed) Published
Background: Animal studies have indicated that 5-HT2A receptors could play a role in arthritic diseases.
Objective: To analyse the binding properties of 5-HT2A receptors in patients with rheumatoid arthritis.
Methods: Using a radioactive binding assay, 43 patients with rheumatoid arthritis were compared with 49 sex and age matched controls for density and affinity (measured as Bmax and Kd) of 5-HT2A serotonin receptors. Genotyping, using polymerase chain reaction, was undertaken to exclude the possibility that differences in the genetic polymorphism T102C for the 5-HT2A receptor determine differences in receptor density.
Results: Mean of Bmax of 5-HT2A receptors in rheumatoid patients was significantly lower than in controls, at 45.3 v 57.4 fmol/mg protein (p = 0.004), but there was no significant difference in Kd. The T102C receptor polymorphism genotypes showed a skewed distribution between the two groups. Even when adjusted for this, there was a significant difference in Bmax between the groups.
Conclusions: The density of 5-HT2A serotonin receptors in patients with rheumatoid arthritis is markedly reduced. This could either reflect a difference involved in the susceptibility to the disease or be a secondary effect of the disease.
Place, publisher, year, edition, pages
2006. Vol. 65, no 6, 816-819 p.
Aged, Arthritis; Rheumatoid/*metabolism, Binding; Competitive, Case-Control Studies, Female, Genotype, Humans, Male, Middle Aged, Polymorphism; Genetic, Radioligand Assay/methods, Receptor; Serotonin; 5-HT2A/*analysis/genetics
Social and Clinical Pharmacy
IdentifiersURN: urn:nbn:se:umu:diva-14157DOI: 10.1136/ard.2005.042473PubMedID: 16699051OAI: oai:DiVA.org:umu-14157DiVA: diva2:153828