Tumor size, vascular density and proliferation as prognostic markers in GS 6 and GS 7 prostate tumors in patients with long follow-up and non-curative treatment
2005 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 48, no 4, 577-583 p.Article in journal (Refereed) Published
Objectives: To investigate the prognostic value of potential markers in localized, Gleason score 6 and 7 prostate cancer (PC).
Methods: From a consecutive series of men with PC diagnosed at transurethral resection (1975-1990),. specimens from 132 patients without metastases, with Gleason score (GS) 6 (n = 80) or 7 (n = 52) tumors followed with watchful waiting were examined. The fraction of resected prostate tissue containing cancer, the micro-vessel density (v.d.) when stained for endoglin or von Willebrand factor (vWf), and the percentage of Ki-67 labeled tumor cells were measured using immunohistochemistry.
Results: High levels of vWf v.d., endoglin v.d., and percent cancer of the TURP specimen were significantly associated with short cancer-specific survival in Kaplan-Meier analysis of all patients with GS 6 and 7 tumors. Interestingly, a combined estimate of percent cancer and vWF v.d. could be used to identify a large subset (50%) of GS 6 tumors with only a 2.5% risk of PC death within 15 years. None of the tested markers gave independent prognostic information for the GS 7 tumors.
Conclusions: Estimates of tumor size and vascular density may identify a large proportion of non-aggressive GS 6, but not GS 7, tumors.
Place, publisher, year, edition, pages
2005. Vol. 48, no 4, 577-583 p.
Age Factors, Aged, Aged; 80 and over, Antigens; CD/metabolism, Follow-Up Studies, Humans, Immunohistochemistry, Ki-67 Antigen/metabolism, Male, Middle Aged, Neoplasm Staging, Neovascularization; Pathologic/blood/surgery, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prostate/*blood supply, Prostatic Neoplasms/blood/blood supply/*pathology/surgery, Receptors; Cell Surface/metabolism, Risk Factors, Severity of Illness Index, Survival Analysis, Time Factors, Transurethral Resection of Prostate, Tumor Burden, Tumor Markers; Biological/*blood, von Willebrand Factor/metabolism
Urology and Nephrology
IdentifiersURN: urn:nbn:se:umu:diva-14259DOI: 10.1016/j.eururo.2005.05.016PubMedID: 15990221OAI: oai:DiVA.org:umu-14259DiVA: diva2:153930