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Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
Umeå University, Faculty of Science and Technology, Chemistry.
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2004 (English)In: ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, Vol. 2, no 21, 3085-90 p.Article in journal (Refereed) Published
Abstract [en]

The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.

Place, publisher, year, edition, pages
2004. Vol. 2, no 21, 3085-90 p.
URN: urn:nbn:se:umu:diva-14265DOI: doi:10.1039/b409678aOAI: diva2:153936
Available from: 2007-05-25 Created: 2007-05-25 Last updated: 2011-01-12Bibliographically approved

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Almqvist, Fredrik
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