umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
Umeå University, Faculty of Science and Technology, Chemistry.
Show others and affiliations
2004 (English)In: ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, Vol. 2, no 21, 3085-90 p.Article in journal (Refereed) Published
Abstract [en]

The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.

Place, publisher, year, edition, pages
2004. Vol. 2, no 21, 3085-90 p.
Identifiers
URN: urn:nbn:se:umu:diva-14265DOI: doi:10.1039/b409678aOAI: oai:DiVA.org:umu-14265DiVA: diva2:153936
Available from: 2007-05-25 Created: 2007-05-25 Last updated: 2011-01-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full texthttp://pubs.rsc.org/ej/OB/2004/B409678A.pdf

Search in DiVA

By author/editor
Almqvist, Fredrik
By organisation
Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 118 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf