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NMR Studies of Lipid Lateral Diffusion in the DMPC/Gramicidin D/Water System: Peptide Aggregation and Obstruction Effects
Umeå University, Faculty of Science and Technology, Chemistry.
Umeå University, Faculty of Science and Technology, Chemistry.
2004 (English)In: Biophysical Journal, Vol. 87, 980-7 p.Article in journal (Refereed) Published
Abstract [en]

The PFG-NMR method has been used in macroscopically oriented bilayers to investigate the effect of the peptide gramicidin D on the lateral diffusion of dimyristoylphosphatidylcholine. By varying both the temperature (21–35°C) and the gramicidin content (0–5 mol %) we have introduced solid obstacles into the lipid liquid crystalline bilayer. It was shown that the obstruction effect exerted by the peptide can be described with several different theoretical models, each based on different premises, and that the fit of the models to experimental data gave reasonable results. We found that each gramicidin molecule was surrounded by approximately one layer of bound lipids and that the obstruction from gel phase patches can be described as small solid obstacles. No evidence of linear aggregates of gramicidin, such as those reported by atomic force microscopy in the gel phase, was found.

Place, publisher, year, edition, pages
2004. Vol. 87, 980-7 p.
URN: urn:nbn:se:umu:diva-14370DOI: doi:10.1529/biophysj.103.038828OAI: diva2:154041
Available from: 2007-05-29 Created: 2007-05-29 Last updated: 2011-01-12Bibliographically approved

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Orädd, GregerLindblom, Göran
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