Multivariate Data Analysis for Enhanced Interpretation of Electrochemical Impedance Spectra of Gramicidin-Ion Interactions in Phospholipid Monolayers
2007 (English)In: Langmuir, Vol. 23, no 9, 5029-32 p.Article in journal (Refereed) Published
This article describes a multifrequency electrochemical impedance study of phospholipid monolayers on a mercury drop electrode in solutions containing electrolytes and gramicidin derivatives: gramicidin A (gA), gramicidin-BOC (g-BOC), and desformylgramicidin (g-des). The impedance spectra have been studied individually (univariate approach) and also transformed using a multivariate data reduction method (multivariate approach). It was shown that the two approaches are complementary. Thus the formation of K+-conducting channels is observed in gA only, and these channels can be distinguished from an interaction of all gramicidin derivatives with Mg2+. An unknown peptide interaction in the monolayer was observed on a slow time scale.
Place, publisher, year, edition, pages
2007. Vol. 23, no 9, 5029-32 p.
IdentifiersURN: urn:nbn:se:umu:diva-14455DOI: 10.1021/la062850jOAI: oai:DiVA.org:umu-14455DiVA: diva2:154126