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The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
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2005 (English)In: J Appl Toxicol, ISSN 0260-437X, Vol. 25, no 4, 328-37 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 25, no 4, 328-37 p.
Keyword [en]
Blotting; Western, Cell Adhesion/drug effects, Electrophoretic Mobility Shift Assay, Enzyme Activation/drug effects, Enzyme Inhibitors/pharmacology, Epithelial Cells/drug effects/pathology, Flavonoids/pharmacology, Flow Cytometry, Intercellular Adhesion Molecule-1/metabolism, Lung/*pathology, Melphalan/*pharmacology, Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Monocytes/drug effects/metabolism, NF-kappa B/*drug effects, Oxazines, Pneumonia/*chemically induced/*pathology, Protein Kinase C/antagonists & inhibitors, Pulmonary Alveoli/drug effects/pathology, RNA; Messenger/biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha/metabolism, Vascular Cell Adhesion Molecule-1/biosynthesis, Xanthenes
Identifiers
URN: urn:nbn:se:umu:diva-15047DOI: doi:10.1002/jat.1070PubMedID: 16025434OAI: oai:DiVA.org:umu-15047DiVA: diva2:154719
Available from: 2007-06-25 Created: 2007-06-25 Last updated: 2011-01-12Bibliographically approved

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Österlund, CamillaSandström, ThomasBucht, Anders
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