Change search
ReferencesLink to record
Permanent link

Direct link
The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).ORCID iD: 0000-0002-8517-8320
Show others and affiliations
2005 (English)In: Plant Cell, ISSN 1040-4651, Vol. 17, no 9, 2527-41 p.Article in journal (Refereed) Published
Abstract [en]

The molecular mechanisms by which the phytohormone auxin coordinates cell division with cell growth and differentiation are largely unknown. Here, we show that in Arabidopsis thaliana E2FB, accumulation and stability are positively regulated by auxin. Coexpression of E2FB, but not of E2FA, with its dimerization partner A, stimulated cell proliferation in the absence of auxin in tobacco (Nicotiana tabacum) Bright Yellow-2 cells. E2FB regulated the entry into both S- and M-phases, the latter corresponding to the activation of a plant-specific mitotic regulator, CDKB1;1. Increased E2FB levels led to shortened cell cycle duration, elevated cell numbers, and extremely small cell sizes. In the absence of auxin, cells elongated with concomitant increase in their ploidy level, but both were strongly inhibited by E2FB. We conclude that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.

Place, publisher, year, edition, pages
2005. Vol. 17, no 9, 2527-41 p.
Keyword [en]
Arabidopsis/cytology/genetics/*metabolism, Arabidopsis Proteins/genetics/*metabolism, Cell Cycle/physiology, Cell Cycle Proteins/genetics/metabolism, Cell Division/*physiology, Cells; Cultured, Cyclin-Dependent Kinases/metabolism, E2F Transcription Factors/genetics/*metabolism, Indoleacetic Acids/*metabolism, Molecular Sequence Data, Plants; Genetically Modified, Transcription Factors/metabolism
URN: urn:nbn:se:umu:diva-15847DOI: doi:10.1105/tpc.105.033761PubMedID: 16055635OAI: diva2:155519
Available from: 2007-08-02 Created: 2007-08-02 Last updated: 2015-04-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bako, Laszlo
By organisation
Department of Plant PhysiologyUmeå Plant Science Centre (UPSC)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 55 hits
ReferencesLink to record
Permanent link

Direct link