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Chromatographic comparison of bupivacaine imprinted polymers prepared in crushed monolith, microsphere, silica-based composite and capillary monolith formats
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2007 (English)In: Journal of Chromatography A, Vol. 1160, no 1-2, 215-26 p.Article in journal (Refereed) Published
Abstract [en]

A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.

Place, publisher, year, edition, pages
2007. Vol. 1160, no 1-2, 215-26 p.
Keyword [en]
Molecularly imprinted polymers, Bupivacaine, Frontal chromatography, Capillary monolith, Microspheres, Iniferter
URN: urn:nbn:se:umu:diva-16014DOI: doi:10.1016/j.chroma.2007.05.057OAI: diva2:155687
Available from: 2007-08-13 Created: 2007-08-13 Last updated: 2011-01-11Bibliographically approved

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Irgum, Knut
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ReferencesLink to record
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