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Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors
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2007 (English)In: Antimicrobial Agents and Chemotherapy, Vol. 51, no 7, 2631-5 p.Article in journal (Refereed) Published
Abstract [en]

Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

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2007. Vol. 51, no 7, 2631-5 p.
URN: urn:nbn:se:umu:diva-16019DOI: doi:10.1128/AAC.01492-06OAI: diva2:155692
Available from: 2007-08-13 Created: 2007-08-13 Last updated: 2011-01-11Bibliographically approved

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Wolf-Watz, HansElofsson, Mikael
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Molecular Biology (Faculty of Science and Technology)Chemistry

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