Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors
2007 (English)In: Antimicrobial Agents and Chemotherapy, Vol. 51, no 7, 2631-5 p.Article in journal (Refereed) Published
Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.
Place, publisher, year, edition, pages
2007. Vol. 51, no 7, 2631-5 p.
IdentifiersURN: urn:nbn:se:umu:diva-16019DOI: doi:10.1128/AAC.01492-06OAI: oai:DiVA.org:umu-16019DiVA: diva2:155692