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Effects of glass ionomers and dental resin composites on viability of beta-cells and insulin release in isolated islets of Langerhans.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Odontology, Dental Materials Science.
2003 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 24, no 21, 3741-3746 p.Article in journal (Refereed) Published
Abstract [en]

Information on the biocompatibility of glass ionomers and resin composites is sparse. To extend the scale of biological testing we evaluated the influence of those materials on insulin secretion at whole organ level in vitro. The effects on insulin secretion of three glass ionomers and two resin composites, aged for 1 week, were studied in isolated mouse islets of Langerhans at basal (5.5mM) and at stimulatory (11.1mM) D-glucose concentrations. In addition, viability of single mouse beta-cells was evaluated. The effect of glass ionomer specimens aged for 1 and 4 months on insulin secretion at 11.1mM D-glucose was also studied. None of the materials affected the viability of the beta-cells. At 5.5mM D-glucose none of the materials affected the insulin secretion. At 11.1mM D-glucose, the glass ionomers only decreased the secretion and glass ionomers aged for 1 month still decreased insulin release whereas after 4 months ageing only one of the glass ionomers affected the release. The result shows a dynamic effect on insulin release of the elements and/or compounds released from the specimens.

Place, publisher, year, edition, pages
2003. Vol. 24, no 21, 3741-3746 p.
Keyword [en]
Biocompatibility; Dental materials; Glass ionomer; Insulin release; Resin composites
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-16058DOI: doi:10.1016/S0142-9612(03)00249-7PubMedID: 12818546OAI: oai:DiVA.org:umu-16058DiVA: diva2:155731
Available from: 2008-02-26 Created: 2008-02-26 Last updated: 2010-06-24Bibliographically approved

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Persson-Sjögren, SolveigSjögren, Göran

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