Change search
ReferencesLink to record
Permanent link

Direct link
Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival.
Show others and affiliations
2006 (English)In: Leukemia, Vol. 20, no 1, 42-7 p.Article in journal (Refereed) Published
Abstract [en]

Combination chemotherapy may induce remission from acute myeloid leukemia (AML), but validated criteria for treatment of elderly are lacking. The remission intention (RI) rate for elderly patients, as reported to the Swedish Leukemia Registry, was known to be different when comparing the six health care regions, but the consequences of different management are unknown. The Leukemia Registry, containing 1672 AML patients diagnosed between 1997 and 2001, with 98% coverage and a median follow-up of 4 years, was completed with data from the compulsory cancer and population registries. Among 506 treated and untreated patients aged 70-79 years with AML (non-APL), there was a direct correlation between the RI rate in each health region (range 36-76%) and the two-year overall survival, with no censored observations (6-21%) (chi-squared for trend=11.3, P<0.001; r2=0.86, P<0.02, nonparametric). A 1-month landmark analysis showed significantly better survival in regions with higher RI rates (P=0.003). Differences could not be explained by demographics, and was found in both de novo and secondary leukemias. The 5-year survival of the overall population aged 70-79 years was similar between the regions. Survival of 70-79-year-old AML patients is better in regions where more elderly patients are judged eligible for remission induction.

Place, publisher, year, edition, pages
2006. Vol. 20, no 1, 42-7 p.
URN: urn:nbn:se:umu:diva-16128PubMedID: 16327841OAI: diva2:155801
Available from: 2007-08-17 Created: 2007-08-17 Last updated: 2011-01-11Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Wahlin, Anders
By organisation
Public Health and Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link