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Age at onset of childhood-onset type 1 diabetes and the development of end-stage renal disease: a nationwide population-based study.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och folkhälsovetenskap.ORCID-id: 0000-0002-5095-3454
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
2006 (Engelska)Ingår i: Diabetes Care, Vol. 29, nr 3, s. 538-42Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: To analyze the impact of age at onset on the development of end-stage renal disease (ESRD) due to diabetic nephropathy in a nationwide population-based cohort with childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS: A record linkage between two nationwide registers, the Swedish Childhood Diabetes Registry, including 12,032 cases with childhood-onset diabetes, and the Swedish Registry for Active Treatment of Uraemia was performed. Log-rank test was used to test differences between cumulative risk curves of developing ESRD due to diabetic nephropathy in three different strata of age at onset (0-4, 5-9, and 10-14 years). RESULTS: At a maximum follow-up of 27 years, 33 patients had developed ESRD due to diabetic nephropathy and all had a diabetes duration >15 years. In total, 4,414 patients had diabetes duration >15 years, and thus the risk in this cohort to develop ESRD was 33 of 4,414 (0.7%). A significant difference in risk of developing ESRD was found between the youngest (0-4 years) and the two older (5-9 and 10-14 years) age-at-onset strata (P = 0.03 and P = 0.001, respectively). A significant difference in the risk of developing ESRD was also found between children with prepubertal (0-4 and 5-9 years, n = 2,424) and pubertal (10-14 years, n = 2000) onset of diabetes (P = 0.002). No patient with onset of diabetes before 5 years of age had developed ESRD. CONCLUSIONS: With a median duration of 21 years in this population-based Swedish cohort with childhood-onset diabetes, <1% of the patients had developed ESRD due to diabetic nephropathy, and a prepubertal onset of diabetes seems to prolong the time to development of ESRD.

Ort, förlag, år, upplaga, sidor
2006. Vol. 29, nr 3, s. 538-42
Identifikatorer
URN: urn:nbn:se:umu:diva-16150PubMedID: 16505502OAI: oai:DiVA.org:umu-16150DiVA, id: diva2:155823
Tillgänglig från: 2008-02-22 Skapad: 2008-02-22 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Svensson, MariaNyström, LennarthDahlquist, G

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Institutionen för folkhälsa och klinisk medicinEpidemiologi och folkhälsovetenskapPediatrik

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