Change search
ReferencesLink to record
Permanent link

Direct link
Gender-specific links between hepatic 11beta reduction of cortisone and adipokines.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Show others and affiliations
2007 (English)In: Obesity (Silver Spring), ISSN 1930-7381, Vol. 15, no 4, 887-894 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Reduction of cortisone to cortisol is mediated by 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), a putative key enzyme in obesity-related complications. Experimental studies suggest that adipokines, notably leptin and tumor necrosis factor-alpha (TNF-alpha), are of importance for 11betaHSD1 activity. We hypothesized that the regulation of hepatic preceptor glucocorticoid metabolism is gender-specific and associated with circulating levels of leptin and TNF-alpha receptors and/or sex hormones. RESEARCH METHODS AND PROCEDURES: A total of 34 males and 38 women (14 premenopausal and 22 postmenopausal) underwent physical examination and fasting blood sampling. Insulin sensitivity was tested by euglycemic hyperinsulinemic clamps, and hepatic 11betaHSD1 enzyme activity was estimated by the conversion of orally-ingested cortisone to cortisol. RESULTS: Hepatic 11betaHSD1 activity was negatively associated with leptin and soluble TNF (sTNF) r1 and sTNFr2 in males. These correlations remained significant after adjustment for age and insulin sensitivity, and for sTNF-alpha receptors also after adjustment of BMI and waist circumference. In contrast, 11beta reduction of cortisone was positively associated to leptin in females after adjustment for BMI and waist circumference. DISCUSSION: Hepatic 11beta reduction shows different links to circulating adipocyte-derived hormones in males and females. This emphasizes the need for further studies on tissue-specific regulation of 11betaHSD1 in both genders.

Place, publisher, year, edition, pages
2007. Vol. 15, no 4, 887-894 p.
Keyword [en]
11-beta-Hydroxysteroid Dehydrogenase Type 1/*metabolism, Adipose Tissue/*metabolism, Adult, Cortisone/*metabolism, Cytokines/*metabolism, Female, Gene Expression Regulation, Humans, Insulin/metabolism, Leptin/metabolism, Liver/metabolism, Male, Middle Aged, Sex Factors, Tumor Necrosis Factor-alpha/metabolism
URN: urn:nbn:se:umu:diva-16341DOI: 10.1038/oby.2007.587PubMedID: 17426324OAI: diva2:156014
Available from: 2007-09-12 Created: 2007-09-12 Last updated: 2013-03-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Mattsson, CeciliaAndersson, JonasEliasson, MatsSöderberg, StefanOlsson, Tommy
By organisation
MedicineDepartment of Public Health and Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 45 hits
ReferencesLink to record
Permanent link

Direct link