Dynamics of platelet activation in diabetic and non-diabetic subjects during the course of an acute myocardial infarction
2007 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 121, no 2, 269-273 p.Article in journal (Refereed) Published
The dynamics of platelet activation during the course of a myocardial infarction is unknown but of great importance in terms of risk assessment and anti-thrombotic therapy. The aim of the present study was sequentially to analyse platelet activation in diabetic and non-diabetic subjects with an acute myocardial infarction.
Materials and methods
We used a sensitive laser light scattering technique to assess platelet aggregation as a measure of activation. Measurements were made on the first, second, third and fifth day in-hospital. Two hundred and forty-three patients with an acute myocardial infarction, of whom 48 had diabetes, were included.
Platelet activation increased until the third in-hospital day in both diabetic and non-diabetic subjects, despite intense anti-thrombotic therapy. The activation was more pronounced in diabetic subjects from the time of hospital admission. Platelet activation tended to decrease after the third in-hospital day.
We conclude that platelet activation increases rapidly at the onset of a myocardial infarction, despite aggressive anti-thrombotic treatment. The activation is more pronounced in diabetic subjects and tends to decrease within a few days. More targeted and effective anti-platelet therapy has the potential further to reduce cardiac and cerebral ischemic events following myocardial infarction and ongoing clinical trials are addressing this issue.
Place, publisher, year, edition, pages
2007. Vol. 121, no 2, 269-273 p.
Myocardial infarction; Diabetes mellitus; Platelet aggregation; Antiplatelet agents
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:umu:diva-16345DOI: 10.1016/j.thromres.2007.04.011PubMedID: 17543372OAI: oai:DiVA.org:umu-16345DiVA: diva2:156018