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Insulin-like growth factor I in pregnancy and maternal risk of breast cancer
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
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2006 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 15, no 12, 2489-2493 p.Article in journal (Refereed) Published
Abstract [en]

Background: The role of insulin-like growth factor (IGF)-I in breast cancer remains controversial, despite numerous reports on the association of the hormone with breast cancer or high-risk mammographic densities. We hypothesized that exposure to elevated IGF-I during early pregnancy, a period characterized by intense cell proliferation in the breasts and in the presence of high concentrations of sex steroids, will be associated with increased maternal risk to develop a breast malignancy.

Methods: The Northern Sweden Maternity Cohort is an ongoing prospective study, collecting blood samples from first-trimester-pregnant women since 1975 as part of screening for infectious diseases. A case-control study (212 cases and 369 controls) was nested among Northern Sweden Maternity Cohort members who delivered singleton babies. RIA was used to measure IGF-I and IGF-II levels. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI).

Results: Breast cancer risk increased with increasing IGF-I (top tertile OR, 1.7; 95% CI, 1.1-2.7). The association was stronger among the primiparous (OR, 2.2; 95% CI, 1.1-4.4) than in the nonprimiparous women (OR, 1.4; 95% CI, 0.7-2.8). Upper-tertile risks seemed to decrease within the <28-, 28 to 33, and >33-year groups of age at sampling, from 2.5 (0.9-7.6) to 2.1 (0.9-5.0) and 1.2 (0.5-2.5), respectively. There was no association of breast cancer with first-trimester-pregnancy IGF-II.

Conclusions: The study offers further evidence that IGF-I is important in breast cancer. Our findings suggest that the adverse effect of IGF-I on the breast may be stronger before the remodeling of the gland induced by a first pregnancy.

Place, publisher, year, edition, pages
Baltimore: Waverly Press , 2006. Vol. 15, no 12, 2489-2493 p.
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URN: urn:nbn:se:umu:diva-16401DOI: 10.1158/1055-9965.EPI-06-0625PubMedID: 17132766ISBN: OAI: oai:DiVA.org:umu-16401DiVA: diva2:156074
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Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2015-04-22Bibliographically approved

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Grankvist, KjellWulff, MarianneLenner, PerHallmans, GöranWadell, GöranLundin, Eva

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