Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
2005 (English)In: Nature, ISSN 1476-4687, Vol. 436, no 7052, 807-11 p.Article in journal (Refereed) Published
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis.
Place, publisher, year, edition, pages
2005. Vol. 436, no 7052, 807-11 p.
Adoptive Transfer, Alleles, Animals, Apoptosis, Apoptosis Regulatory Proteins, Burkitt Lymphoma/*genetics/*metabolism/pathology, Carrier Proteins/metabolism, Cell Cycle Proteins/metabolism, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Genes; myc/*genetics, Humans, Membrane Proteins/metabolism, Mice, Mice; Inbred C57BL, Mutation/*genetics, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, Proto-Oncogene Proteins c-myc/*genetics/*metabolism, Stem Cell Transplantation, Tumor Suppressor Protein p14ARF/metabolism, Tumor Suppressor Protein p53/*metabolism
IdentifiersURN: urn:nbn:se:umu:diva-16702PubMedID: 16094360OAI: oai:DiVA.org:umu-16702DiVA: diva2:156375