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Nfkb 1 is dispensable for Myc-induced lymphomagenesis.
Umeå University, Faculty of Science and Technology, Molecular Biology (Faculty of Science and Technology). (Nilsson)
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2005 (English)In: Oncogene, ISSN 0950-9232, Vol. 24, no 41, 6231-40 p.Article in journal (Refereed) Published
Abstract [en]

Rel/NF-kappaB transcription factors are critical arbiters of immune responses, cell survival, and transformation, and are frequently deregulated in cancer. The p50 NF-kappaB 1 component of Rel/NF-kappaB DNA-binding dimers regulates genes involved in both cell cycle traverse and apoptosis. Nfkb 1 loss accelerates B cell growth and leads to increased B cell turnover in vivo, phenotypes akin to those manifested in B cells of Emu-Myc transgenic mice, a model of human Burkitt lymphoma. Interestingly, Emu-Myc B cells express reduced levels of cytoplasmic and nuclear NF-kappaB 1 and have reduced Rel/NF-kappaB DNA-binding activity, suggesting that Myc-mediated repression of NF-kappaB 1 might mediate its proliferative and apoptotic effects on B cells. Furthermore, Nfkb 1 expression was reduced in the majority of Emu-Myc lymphomas and was also suppressed in human Burkitt lymphoma. Nonetheless, loss of Nfkb 1 did not appreciably affect Myc's proliferative or apoptotic responses in B cells and had no effect on lymphoma development in Emu-Myc mice. Therefore, Nfkb 1 is dispensable for Myc-induced lymphomagenesis.. Oncogene (2005) 24, 6231-6240

Place, publisher, year, edition, pages
2005. Vol. 24, no 41, 6231-40 p.
Keyword [en]
Animals, Base Sequence, Burkitt Lymphoma/genetics, DNA/metabolism, DNA Primers, Humans, Mice, Mice; Inbred C57BL, Mice; Knockout, Mice; Transgenic, NF-kappa B p50 Subunit/genetics/*physiology, Proto-Oncogene Proteins c-myc/genetics/*physiology
URN: urn:nbn:se:umu:diva-16705PubMedID: 15940251OAI: diva2:156378
Available from: 2007-10-09 Created: 2007-10-09 Last updated: 2011-01-12Bibliographically approved

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