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The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.
Umeå University, Faculty of Science and Technology, Molecular Biology (Faculty of Science and Technology).
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2005 (English)In: Mol Cell Biol, ISSN 0270-7306, Vol. 25, no 6, 2395-405 p.Article in journal (Refereed) Published
Abstract [en]

The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.

Place, publisher, year, edition, pages
2005. Vol. 25, no 6, 2395-405 p.
Keyword [en]
Animals, Apoptosis, B-Lymphocytes/metabolism, Burkitt Lymphoma/genetics/*metabolism, Cell Proliferation, Child, DNA-Binding Proteins/genetics/*metabolism, Female, Humans, Leukemia; B-Cell; Acute/genetics/*metabolism, Male, Mice, Mice; Transgenic, Mutation/genetics, Proto-Oncogene Proteins c-ets, Proto-Oncogene Proteins c-myc/*metabolism, Suppression; Genetic, Transcription Factors/genetics/*metabolism, Tumor Suppressor Protein p53/genetics, Up-Regulation/genetics
URN: urn:nbn:se:umu:diva-16706PubMedID: 15743832OAI: diva2:156379
Available from: 2007-10-09 Created: 2007-10-09 Last updated: 2011-01-12Bibliographically approved

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