Change search
ReferencesLink to record
Permanent link

Direct link
Prediction of all-cause mortality in a patient population with hypertension and type 2 DM by using traditional risk factors and serum-phosphate, -calcium and -magnesium.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Social Sciences, Statistics.
Faculty of Medicine, Public Health and Clinical Medicine.
2007 (English)In: Acta Biabetologica, ISSN 0940-5429 (Print) 1432-5233 (Online), Vol. 44, no 3Article in journal (Refereed) Published
Abstract [en]

The aim of this study is to investigate whether the prediction of all-cause mortality from traditional risk factors is improved by adding electrolytes (serum-phosphate (S-P), serum-calcium (S-Ca) and serum-magnesium (S-Mg)) in a Cox regression. The study uses an 18-year follow-up of patients (n=2504) referred by physicians in primary health care and hospitals to the Vindeln Patient Education (VPE) Center, mainly with a diagnosis of hypertension (HT), type 2 diabetes mellitus (DM) and/or obesity.

Cox regression, with the latest registered value and baseline values for risk factors, was used to study all-cause mortality in men and women. 221 out of 1096 men and 157 out of 1408 women died during the 18-year follow-up (20% and 11% respectively). The Cox regression analysis reveals that high blood glucose (B-Glu) and low S-Mg were significantly associated with increased all-cause mortality in the whole patient population as well as in men and women separately. Among women, type 2 DM and systolic blood pressure (SBP) and among men, high S-Ca, S-P, S-urate and body mass index (BMI) were the main predictors of all-cause mortality. There is significantly improved prediction of all-cause mortality with electrolytes added to the traditional risk factors. High B-Glu and low S-Mg in both men and women, and high S-Ca and S-P in men, are significantly associated with all-cause mortality. The metabolic disturbance in this high-risk group of patients can be more fully understood if ionic imbalance is included in the prediction of mortatlity.

Place, publisher, year, edition, pages
2007. Vol. 44, no 3
Keyword [en]
All-cause mortality - Calcium - Magnesium - Metabolic syndrome - Phosphate - Sex
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-16831DOI: doi:10.1007/s00592-007-0254-6OAI: diva2:156504
Available from: 2007-12-06 Created: 2007-12-06 Last updated: 2011-01-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Håglin, LenaTörnkvist, Birgitta
By organisation
Family MedicineStatisticsPublic Health and Clinical Medicine
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link