Pharmacokinetic and behavioral effects of allopregnanolone in healthy women
2006 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 186, no 3, 414-424 p.Article in journal (Refereed) Published
Rationale The behavioral effects of allopregnanolone (3α-hydroxy-5α-pregnan-20-one) in women are not known. Objective Allopregnanolone, a neuroactive steroid secreted by the mammalian ovary, exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABAA receptors. The purpose of this study was to evaluate the behavioral effects of allopregnanolone in healthy women. Methods Ten healthy women were given three increasing intravenous doses of allopregnanolone in the follicular phase of the menstrual cycle. Saccadic eye movement parameters and visual analogue scales of sedation were used to evaluate the behavioral response of allopregnanolone. Repeated blood samples for analyses of allopregnanolone were drawn throughout the study day. Results Exogenously administered allopregnanolone decreases saccadic eye movement parameters and increases subjective ratings of sedation that correlate with increased serum concentrations of this neuroactive steroid. Conclusion The behavioral effects of allopregnanolone are similar to that of its 5β-stereoisomer, pregnanolone (3α-hydroxy-5β-pregnan-20-one). Apart from fatigue and mild nausea, allopregnanolone given in a cumulative dose of 0.09 mg/kg did not have any adverse effects.
Place, publisher, year, edition, pages
2006. Vol. 186, no 3, 414-424 p.
Adult, Animals, Chickens, Egg Yolk/immunology, Female, Humans, Hypnotics and Sedatives/blood/pharmacokinetics/*pharmacology, Immune Sera/immunology, Immunoglobulins/immunology, Pregnanolone/blood/pharmacokinetics/*pharmacology, Saccades/*drug effects
Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:umu:diva-16931DOI: 10.1007/s00213-005-0148-7PubMedID: 16177884OAI: oai:DiVA.org:umu-16931DiVA: diva2:156604