Change search
ReferencesLink to record
Permanent link

Direct link
Dosage compensation, the origin and the afterlife of sex chromosomes.
Umeå University, Faculty of Science and Technology, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Science and Technology).
2006 (English)In: Chromosome Res, ISSN 0967-3849, Vol. 14, no 4, 417-31 p.Article in journal (Other academic) Published
Abstract [en]

Over the past 100 years Drosophila has been developed into an outstanding model system for the study of evolutionary processes. A fascinating aspect of evolution is the differentiation of sex chromosomes. Organisms with highly differentiated sex chromosomes, such as the mammalian X and Y, must compensate for the imbalance in gene dosage that this creates. The need to adjust the expression of sex-linked genes is a potent force driving the rise of regulatory mechanisms that act on an entire chromosome. This review will contrast the process of dosage compensation in Drosophila with the divergent strategies adopted by other model organisms. While the machinery of sex chromosome compensation is different in each instance, all share the ability to direct chromatin modifications to an entire chromosome. This review will also explore the idea that chromosome-targeting systems are sometimes adapted for other purposes. This appears the likely source of a chromosome-wide targeting system displayed by the Drosophila fourth chromosome

Place, publisher, year, edition, pages
2006. Vol. 14, no 4, 417-31 p.
Keyword [en]
Animals, Chromosomes/genetics, Dosage Compensation; Genetic/*genetics, Drosophila/*genetics, Drosophila Proteins/genetics, Female, Gene Expression Regulation, Male, Recombination; Genetic/genetics, Sex Chromosomes/*genetics, Sex Factors, Transcription Factors, X Chromosome Inactivation/genetics
URN: urn:nbn:se:umu:diva-17031PubMedID: 16821137OAI: diva2:156704
Available from: 2007-10-26 Created: 2007-10-26 Last updated: 2011-01-11Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Larsson, Jan
By organisation
Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Science and Technology)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 47 hits
ReferencesLink to record
Permanent link

Direct link