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Insights into social insects from the genome of the honeybee Apis mellifera.
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine). (Dan Hultmark)
2006 (English)In: Nature, ISSN 1476-4687, Vol. 443, no 7114, 931-49 p.Article in journal (Refereed) Published
Abstract [en]

Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

Place, publisher, year, edition, pages
2006. Vol. 443, no 7114, 931-49 p.
Keyword [en]
Animals, Base Composition, Bees/*genetics/growth & development/*physiology, Behavior; Animal, DNA Transposable Elements/genetics, Evolution; Molecular, Female, Gene Expression Regulation/genetics, Genes; Insect/genetics, Genome; Insect/*genetics, Genomics, Immunity/genetics, Male, Molecular Sequence Data, Phylogeny, Physical Chromosome Mapping, Proteome/genetics, Reproduction/genetics, Signal Transduction/genetics, Social Behavior, Telomere/genetics
URN: urn:nbn:se:umu:diva-17047PubMedID: 17073008OAI: diva2:156720
The Honeybee Genome Sequencing Consortium includes authors from 90 labs. Dan Hultmark contributed to the analysis of genes involved in immunityAvailable from: 2007-10-28 Created: 2007-10-28 Last updated: 2011-01-11Bibliographically approved

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