A family of Turandot-related genes in the humoral stress response of Drosophila.
2001 (English)In: Biochem Biophys Res Commun, ISSN 0006-291X, Vol. 284, no 4, 998-1003 p.Article in journal (Refereed) Published
The Drosophila Turandot A (TotA) gene was recently shown to encode a stress-induced humoral factor which gives increased resistance to the lethal effects of high temperature. Here we show that TotA belongs to a family of eight Tot genes distributed at three different sites in the Drosophila genome. All Tot genes are induced under stressful conditions such as bacterial infection, heat shock, paraquat feeding or exposure to ultraviolet light, suggesting that all members of this family play a role in Drosophila stress tolerance. The induction of the Tot genes differs in important respects from the heat shock response, such as the strong but delayed response to bacterial infection seen for several of the genes.
Place, publisher, year, edition, pages
2001. Vol. 284, no 4, 998-1003 p.
Amino Acid Sequence, Animals, Drosophila melanogaster/*genetics/physiology, Female, Gene Expression Regulation, Heat, Heat-Shock Proteins/chemistry/*genetics, Insect Proteins/chemistry/*genetics, Molecular Sequence Data, Multigene Family, Open Reading Frames, Reverse Transcriptase Polymerase Chain Reaction, Sequence Alignment, Sequence Homology; Amino Acid, Stress, Transcription; Genetic
IdentifiersURN: urn:nbn:se:umu:diva-17065PubMedID: 11409894OAI: oai:DiVA.org:umu-17065DiVA: diva2:156738