Expression and evolution of the Drosophila attacin/diptericin gene family.
2000 (English)In: Biochem Biophys Res Commun, ISSN 0006-291X, Vol. 279, no 2, 574-81 p.Article in journal (Refereed) Published
We describe the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB). Their structures support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. AttC is similar to the nearby AttA and AttB genes. AttD is more divergent and located on a different chromosome. Intriguingly, AttD may encode an intracellular attacin. DptB is linked in tandem to the closely related Diptericin. However, the DptB gene product contains a furin-like cleavage site and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in imd mutants, and unexpectedly also in Tl(-) mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling.
Place, publisher, year, edition, pages
2000. Vol. 279, no 2, 574-81 p.
Amino Acid Sequence, Animals, Anti-Infective Agents/chemistry, Drosophila/classification/*genetics, Drosophila Proteins, Drosophila melanogaster/genetics, Evolution, Evolution; Molecular, Genes; Insect, Insect Proteins/chemistry/*genetics, Insects/classification/*genetics, Molecular Sequence Data, Multigene Family, Phylogeny, Protein Isoforms/chemistry/genetics, Sequence Alignment, Sequence Homology; Amino Acid
IdentifiersURN: urn:nbn:se:umu:diva-17071DOI: 10.1006/bbrc.2000.3988PubMedID: 11118328OAI: oai:DiVA.org:umu-17071DiVA: diva2:156744