umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cloning, mapping and mutational analysis of the S-adenosylmethionine decarboxylase gene in Drosophila melanogaster.
Umeå University, Faculty of Science and Technology, Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Molecular Biology (Faculty of Science and Technology).
1997 (English)In: Mol Gen Genet, ISSN 0026-8925, Vol. 256, no 6, 652-60 p.Article in journal (Other academic) Published
Abstract [en]

S-adenosylmethionine decarboxylase is a key enzyme in the synthesis of polyamines. These small cationic molecules are required for growth and development in all organisms. A wealth of biological processes, including synthesis of DNA and protein and condensation of chromatin, involve polyamines. Inhibition of polyamine synthesis has been proposed for treatment of cancer but this requires more knowledge about the in vivo function of polyamines. We report here the cloning of the S-adenosylmethionine decarboxylase gene from Drosophila melanogaster and the analysis of corresponding mutants. The mutant phenotypes are similar to those previously described for ribosomal protein genes (Minutes) and rRNA genes (bobbed). This work elucidates the in vivo consequences of impaired polyamine synthesis with respect to the development of a whole animal.

Place, publisher, year, edition, pages
1997. Vol. 256, no 6, 652-60 p.
Keyword [en]
Adenosylmethionine Decarboxylase/*genetics, Amino Acid Sequence, Animal Population Groups/genetics, Animals, Base Sequence, Chromatin/genetics/ultrastructure, Chromosome Mapping, Cloning; Molecular, DNA Mutational Analysis, Drosophila melanogaster/enzymology/*genetics, Genes; Insect, Genetic Complementation Test, Insect Proteins/*genetics, Molecular Sequence Data, Phenotype, Plants/genetics, Polyamines/metabolism, Sequence Alignment, Sequence Homology; Amino Acid, Species Specificity
Identifiers
URN: urn:nbn:se:umu:diva-17254PubMedID: 9435790OAI: oai:DiVA.org:umu-17254DiVA: diva2:156927
Available from: 2007-11-07 Created: 2007-11-07 Last updated: 2011-01-15Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=9435790&dopt=Citation

Search in DiVA

By author/editor
Larsson, JanRasmuson-Lestander, Åsa
By organisation
Molecular Biology (Faculty of Science and Technology)

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 56 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf