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Periodontitis is associated with a low concentration of vitamin C in plasma.
Umeå University, Faculty of Medicine, Odontology, Oral Microbiology.
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2003 (English)In: Clinical and Diagnostic Laboratory Immunology, ISSN 1071-412X, Vol. 10, no 5, 897-902 p.Article in journal (Refereed) Published
Abstract [en]

This study aimed to clarify how concentrations of vitamin C in plasma relate to the serology of periodontitis. The random sample used comprised 431 men, 194 from Finland and 237 from Russia. The plasma vitamin C concentration was determined by o-phtaldialdehyde-fluorometry, and serum immunoglobulin G antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by a multiserotype enzyme-linked immunosorbent assay (ELISA). The mean plasma vitamin C concentration was higher (P < 0.001) in Finnish subjects (mean +/- standard deviation, 4.5 +/- 2.8 mg/liter) than in Russian subjects (1.4 +/- 1.8 mg/liter). Mean antibody levels to both A. actinomycetemcomitans (4.7 +/- 3.6 versus 5.2 +/- 3.1 ELISA units [P = 0.05]) and P. gingivalis (5.7 +/- 2.5 versus 7.6 +/- 2.9 ELISA units [P < 0.001]) were lower in Finnish men than in Russian men. In the combined Finnish and Russian population, the antibody levels to P. gingivalis were negatively correlated with vitamin C concentrations (r = -0.22; P < 0.001); this association remained statistically significant (P = 0.010) in a linear regression model after adjustment for confounding factors. The proportion of P. gingivalis-seropositive subjects decreased with increasing vitamin C concentrations (P for trend, <0.01), but no trend was seen among A. actinomycetemcomitans-seropositive subjects. In conclusion, P. gingivalis infection is associated with low concentrations of vitamin C in plasma, which may increase colonization of P. gingivalis or disturb the healing of the infected periodontium.

Place, publisher, year, edition, pages
2003. Vol. 10, no 5, 897-902 p.
URN: urn:nbn:se:umu:diva-17420DOI: 10.1128/CDLI.10.5.897-902.2003PubMedID: 12965924OAI: diva2:157093
Available from: 2007-11-08 Created: 2007-11-08 Last updated: 2009-10-05Bibliographically approved

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Asikainen, Sirkka
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Oral Microbiology

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