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Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine).
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2006 (English)In: Dev Genes Evol, ISSN 0949-944X, Vol. 216, no 1, 10-8 p.Article in journal (Refereed) Published
Abstract [en]

Midkine (MK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. To date, this family of proteins has been implicated in multiple processes, such as growth, survival, and migration of various cells, and has roles in neurogenesis and epithelial-mesenchymal interaction during organogenesis. In this report, we have characterized two members of the MK/PTN family of proteins in Drosophila, named Miple1 and Miple2, from Midkine and Pleiotrophin. Drosophila miple1 and miple2 encode secreted proteins which are expressed in spatially restricted, nonoverlapping patterns during embryogenesis. Expression of miple1 can be found at high levels in the central nervous system, while miple2 is strongly expressed in the developing midgut endoderm. The identification of homologues of the MK/PTN family in this genetically tractable model organism should allow an analysis of their function during complex developmental processes.

Place, publisher, year, edition, pages
2006. Vol. 216, no 1, 10-8 p.
Keyword [en]
Amino Acid Sequence, Animals, COS Cells, Carrier Proteins/chemistry/*genetics/secretion, Cells; Cultured, Cercopithecus aethiops, Cytokines/chemistry/*genetics/secretion, Drosophila Proteins/chemistry/*genetics, Drosophila melanogaster/*embryology/*genetics, Humans, Molecular Sequence Data, Multigene Family
Identifiers
URN: urn:nbn:se:umu:diva-17926PubMedID: 16220264OAI: oai:DiVA.org:umu-17926DiVA: diva2:157599
Available from: 2007-11-23 Created: 2007-11-23 Last updated: 2011-01-11Bibliographically approved

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PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16220264&dopt=Citation

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