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Evolution of genes and genomes on the Drosophila phylogeny.
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Pathogenesis (UCMP) (Faculty of Medicine).
2007 (English)In: Nature, ISSN 1476-4687, Vol. 450, no 7167, 203-18 p.Article in journal (Refereed) Published
Abstract [en]

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

Place, publisher, year, edition, pages
2007. Vol. 450, no 7167, 203-18 p.
Identifiers
URN: urn:nbn:se:umu:diva-17941PubMedID: 17994087OAI: oai:DiVA.org:umu-17941DiVA: diva2:157614
Note
Drosophila 12 Genomes Consortium includes authors from 102 labs. Dan Hultmark contributed to the analysis of genes involved in immunityAvailable from: 2007-11-23 Created: 2007-11-23 Last updated: 2011-01-11Bibliographically approved

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CiteExportLink to record
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Citation style
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