Change search
ReferencesLink to record
Permanent link

Direct link
Epidemiology of Kaposi's sarcoma herpesvirus (HHV8) in Västerbotten county, Sweden.
Microbiology-Immunology and Virology Department, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Epidemiology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0001-9581-3845
Show others and affiliations
2006 (English)In: Journal of Medical Virology, ISSN 0146-6615, E-ISSN 1096-9071, Vol. 78, no 3, 372-378 p.Article in journal (Refereed) Published
Abstract [en]

A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Västerbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immunofluorescence assay to latent and lytic HHV8 antigens. Buffy coat DNA was also analyzed for viral DNA using real time PCR assay. HHV8 DNA was not detectable in any one of the buffy coat samples. Eighty-four subjects (16.2%) were HHV8 seropositive, 14.4% for the lytic HHV8 antigen, and 1.7% for the latent HHV8 antigen. HHV8 seroprevalences were not associated significantly with sex or age. HHV8 seropositivity was more common among smokers (OR: 1.95, 95% CI: 1.02–3.75), but was less common among consumers of wine and spirits (OR: 0.44, 95% CI: 0.25–0.77 and OR: 0.50, 95% CI: 0.26–0.95, respectively). In summary, HHV8 has an intermediate high and stable seroprevalence rate in Northern Sweden, but environmental determinants that can explain the viral distribution were not found. J. Med. Virol. 78:372–378, 2006. © 2006 Wiley-Liss, Inc.


Place, publisher, year, edition, pages
New York: Alan R. Liss , 2006. Vol. 78, no 3, 372-378 p.
Keyword [en]
Adult, Age Factors, Antibodies; Viral/blood, DNA; Viral/blood, Drinking Behavior, Female, Fluorescent Antibody Technique; Indirect, Herpesviridae Infections/*epidemiology/genetics/immunology/*virology, Herpesvirus 8; Human/*genetics/*immunology, Humans, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Sarcoma; Kaposi/epidemiology, Seroepidemiologic Studies, Sex Factors, Smoking, Statistics, Sweden/epidemiology, Viral Proteins/immunology
URN: urn:nbn:se:umu:diva-18010DOI: 10.1002/jmv.20549PubMedID: 16419115OAI: diva2:157683
Available from: 2007-11-26 Created: 2007-11-26 Last updated: 2015-04-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ågren, ÅsaHallmans, GöranWadell, Göran
By organisation
Department of Public Health and Clinical MedicineVirology
In the same journal
Journal of Medical Virology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link