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Reducing intracranial pressure may increase survival among patients with bacterial meningitis
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases. (Clas Ahlm)
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2004 (English)In: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 38, no 3, 384-390 p.Article in journal (Refereed) Published
Abstract [en]

We reported findings concerning continuous intracranial pressure (ICP) and cerebral perfusion pressure (CPP) measurements and mortality in patients with severe bacterial meningitis treated on the basis of an ICP-targeted approach. Eighteen patients with severe bacterial meningitis were admitted for neurointensive care at Umeå University Hospital (Umeå, Sweden). In 15 patients, ICP was measured continuously through an ICP measuring device. During care, all patients but one developed intracranial hypertension with an ICP of ⩾15 mm Hg (14 [93%] of 15 patients). Ten (67%) of 15 patients survived and were discharged, and 5 patients (33%) died. Mean ICP was significantly higher and CPP was markedly decreased in nonsurvivors, compared with survivors. Among the survivors, ICP was gradually reduced. Treatment of patients with severe bacterial meningitis should include neurointensive care and continuous ICP measurement. Increased ICP may be reduced by using the ICP-targeted therapy that closely resembles the “Lund concept.”

Place, publisher, year, edition, pages
Chicago: Univ. of Chicago Press , 2004. Vol. 38, no 3, 384-390 p.
Keyword [en]
Adolescent, Adult, Child, Preschool, Female, Humans, Infant, Intracranial Hypertension/etiology/mortality/*therapy, Intracranial Pressure, Male, Meningitis, Bacterial/*mortality/physiopathology, Middle Aged, Survival Analysis
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-18103DOI: 10.1086/380970PubMedID: 14727209OAI: oai:DiVA.org:umu-18103DiVA: diva2:157776
Available from: 2008-01-08 Created: 2008-01-08 Last updated: 2017-12-14Bibliographically approved

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Lindvall, PeterAhlm, ClasEricsson, MatsGothefors, LeifNaredi, SilvanaKoskinen, Lars-Owe D
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