Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hypothesis: Do LRIG proteins regulate stem cell quiescence by promoting BMP signaling?
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0001-8849-6810
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.ORCID iD: 0000-0001-6891-6996
2023 (English)In: Stem Cell Reviews and Reports, ISSN 2629-3269, Vol. 19, no 1, p. 59-66Article, review/survey (Refereed) Published
Abstract [en]

Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins are evolutionarily conserved integral membrane proteins. Mammalian LRIG1 regulates stem cell quiescence in various tissue compartments, including compartments in the epidermis, oral mucosa, intestines, neural system, and incisors. The planarian LRIG1 homolog regulates the quiescence of multipotent neoblasts. The mechanism through which LRIG proteins regulate stem cell quiescence has not been well documented, although it is generally assumed that LRIG1 regulates the epidermal growth factor receptor (EGFR) or other receptor tyrosine kinases. However, Lrig-null (Lrig1-/-;Lrig2-/-; and Lrig3-/-) mouse embryonic fibroblasts (MEFs) have been recently found to exhibit apparently normal receptor tyrosine kinase functions. Moreover, bone morphogenetic protein (BMP) signaling has been shown to depend on LRIG1 and LRIG3 expression. BMPs are well-known regulators of stem cell quiescence. Here, we hypothesize that LRIG1 might regulate stem cell quiescence by promoting BMP signaling.

HYPOTHESIS: Based on recent findings, it is hypothesized that LRIG1 regulates stem cell quiescence in mammalian tissues as well as in planarian neoblasts by promoting BMP signaling.

Place, publisher, year, edition, pages
Springer, 2023. Vol. 19, no 1, p. 59-66
Keywords [en]
BMP, EGF, LRIG1, Quiescence, Stem cell
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-198922DOI: 10.1007/s12015-022-10442-9ISI: 000840596100002PubMedID: 35969315Scopus ID: 2-s2.0-85135895107OAI: oai:DiVA.org:umu-198922DiVA, id: diva2:1694582
Available from: 2022-09-09 Created: 2022-09-09 Last updated: 2024-07-02Bibliographically approved

Open Access in DiVA

fulltext(1420 kB)84 downloads
File information
File name FULLTEXT02.pdfFile size 1420 kBChecksum SHA-512
8d1a366132d120a6572bbd38a53e07b9f095dd4d5bef3faf4cd1a9d6894b8f5eb24e3718114fdf4089d63bf7e9f5b5b0f0f60b2d46e2e346fe19e49ceb15ab06
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Herdenberg, CarlHedman, Håkan

Search in DiVA

By author/editor
Herdenberg, CarlHedman, Håkan
By organisation
Oncology
Cancer and OncologyCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 102 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 387 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf