Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Brain o-glcnacylation: from molecular mechanisms to clinical phenotype
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
2023 (English)In: Advances in neurobiology, ISSN 2190-5215, Vol. 29, p. 255-280Article in journal (Refereed) Published
Abstract [en]

O-GlcNAc is the attachment of β-N-acetylglucosamine to the hydroxyl group of serine and threonine in nuclear and cytoplasmic proteins. It is generally not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of the tissues where O-GlcNAc is the most highly expressed and deletion of neuronal O-GlcNAc leads to death early in development. O-GlcNAc is also important for normal adult brain function, where dynamic processes like learning and memory at least in part depend on the modification of specific proteins by O-GlcNAc. Conversely, too much or too little O-GlcNAc in the brain contributes to several disorders including obesity, intellectual disability and Alzheimer's disease. In this chapter, we describe the expression and regulation of O-GlcNAc in the nervous system.

Place, publisher, year, edition, pages
Springer Nature, 2023. Vol. 29, p. 255-280
Keywords [en]
Alzheimer’s disease, Food intake, Learning and memory, Neurodegeneration, Nutrient sensing, O-GlcNAc, O-linked N-acetylglucosamine, Obesity, Post-translational modifications, Signaling
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-200660DOI: 10.1007/978-3-031-12390-0_9PubMedID: 36255678Scopus ID: 2-s2.0-85140171507OAI: oai:DiVA.org:umu-200660DiVA, id: diva2:1709080
Available from: 2022-11-07 Created: 2022-11-07 Last updated: 2022-11-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Uygar, BatuhanLagerlöf, Olof

Search in DiVA

By author/editor
Uygar, BatuhanLagerlöf, Olof
By organisation
Psychiatry
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 608 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf