Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Regulatory roles of RNA modifications in breast cancer
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-5389-244x
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-2374-2045
2021 (English)In: NAR Cancer, E-ISSN 2632-8674, Vol. 3, no 3, article id zcab036Article, review/survey (Refereed) Published
Abstract [en]

Collectively referred to as the epitranscriptome, RNA modifications play important roles in gene expression control regulating relevant cellular processes. In the last few decades, growing numbers of RNA modifications have been identified not only in abundant ribosomal (rRNA) and transfer RNA (tRNA) but also in messenger RNA (mRNA). In addition, many writers, erasers and readers that dynamically regulate the chemical marks have also been characterized. Correct deposition of RNA modifications is prerequisite for cellular homeostasis, and its alteration results in aberrant transcriptional programs that dictate human disease, including breast cancer, the most frequent female malignancy, and the leading cause of cancer-related death in women. In this review, we emphasize the major RNA modifications that are present in tRNA, rRNA and mRNA. We have categorized breast cancer-associated chemical marks and summarize their contribution to breast tumorigenesis. In addition, we describe less abundant tRNA modifications with related pathways implicated in breast cancer. Finally, we discuss current limitations and perspectives on epitranscriptomics for use in therapeutic strategies against breast and other cancers.

Place, publisher, year, edition, pages
Oxford University Press, 2021. Vol. 3, no 3, article id zcab036
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-202959DOI: 10.1093/narcan/zcab036ISI: 000925411800012PubMedID: 34541538Scopus ID: 2-s2.0-85126281516OAI: oai:DiVA.org:umu-202959DiVA, id: diva2:1727021
Available from: 2023-01-14 Created: 2023-01-14 Last updated: 2023-09-05Bibliographically approved

Open Access in DiVA

fulltext(3890 kB)123 downloads
File information
File name FULLTEXT01.pdfFile size 3890 kBChecksum SHA-512
c86ec18f2144060a2d6e6431420a719ea60e2a05273474069ab0942bce5c2b794882b4fcf38a30588e74bbfc3f009f635a94236f381a9b3d77fe00f61c20ac5d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Kumari, KanchanGroza, PaulaAguilo, Francesca

Search in DiVA

By author/editor
Kumari, KanchanGroza, PaulaAguilo, Francesca
By organisation
Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Department of Molecular Biology (Faculty of Medicine)
Cancer and OncologyCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 131 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 203 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf