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An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients
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2008 (English)In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 93, no 11, 1734-1738 p.Article in journal (Refereed) Published
Abstract [en]

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.

Place, publisher, year, edition, pages
Pavia: Ferrata Storti Foundation, 2008. Vol. 93, no 11, 1734-1738 p.
Keyword [en]
p14ARF, p53, 9p21, leukemia
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URN: urn:nbn:se:umu:diva-18917DOI: 10.3324/haematol.13227ISI: 000207786500013PubMedID: 18728022OAI: diva2:175134
Available from: 2009-02-27 Created: 2009-02-27 Last updated: 2016-08-15Bibliographically approved

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Lazarevic, Vladimir Lj
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