Accelerometer derived physical activity and subclinical coronary and carotid atherosclerosis: cross-sectional analyses in 22 703 middle-aged men and women in the SCAPIS studyDepartment of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Radiology, Institute of Clinical Sciences, University of Gothenburg, Göteborg, Sweden.
Department of Health, Medicine and Caring Sciences and Department of Clinical Physiology, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
Department of Clinical Sciences, Lund University, Malmö, Sweden.
Department of Health, Medicine and Caring Sciences and Department of Clinical Physiology, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Radiology, Institute of Clinical Sciences, University of Gothenburg, Göteborg, Sweden.
Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Radiology, Institute of Clinical Sciences, University of Gothenburg, Göteborg, Sweden.
Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Cardiology, Skåne University Hospital Malmö, Malmö, Sweden.
Medical Image Centre, Uppsala University Hospital, Uppsala, Sweden; Department of Surgical Sciences and Radiology, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
Department of Cardiology and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Clinical Physiology, Skåne University Hospital, Lund, Sweden.
Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Radiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Clinical Sciences, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden.
Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Internal Medicine, University Hospital, Malmö, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Department of Cardiology, Gothenburg, Sweden.
Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden.
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2023 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 13, no 11, article id e073380
Article in journal (Refereed) Published
Abstract [en]
Objectives: The aim included investigation of the associations between sedentary (SED), low-intensity physical activity (LIPA), moderate-to-vigorous intensity PA (MVPA) and the prevalence of subclinical atherosclerosis in both coronaries and carotids and the estimated difference in prevalence by theoretical reallocation of time in different PA behaviours.
Design: Cross-sectional.
Setting: Multisite study at university hospitals.
Participants: A total of 22 670 participants without cardiovascular disease (51% women, 57.4 years, SD 4.3) from the population-based Swedish CArdioPulmonary bioImage study were included. SED, LIPA and MVPA were assessed by hip-worn accelerometer.
Primary and secondary outcomes: Any and significant subclinical coronary atherosclerosis (CA), Coronary Artery Calcium Score (CACS) and carotid atherosclerosis (CarA) were derived from imaging data from coronary CT angiography and carotid ultrasound.
Results: High daily SED (>70% ≈10.5 hours/day) associated with a higher OR 1.44 (95% CI 1.09 to 1.91), for significant CA, and with lower OR 0.77 (95% CI 0.63 to 0.95), for significant CarA. High LIPA (>55% ≈8 hours/day) associated with lower OR for significant CA 0.70 (95% CI 0.51 to 0.96), and CACS, 0.71 (95% CI 0.51 to 0.97), but with higher OR for CarA 1.41 (95% CI 1.12 to 1.76). MVPA above reference level, >2% ≈20 min/day, associated with lower OR for significant CA (OR range 0.61-0.67), CACS (OR range 0.71-0.75) and CarA (OR range 0.72-0.79). Theoretical replacement of 30 min of SED into an equal amount of MVPA associated with lower OR for significant CA, especially in participants with high SED 0.84 (95% CI 0.76 to 0.96) or low MVPA 0.51 (0.36 to 0.73).
Conclusions: MVPA was associated with a lower risk for significant atherosclerosis in both coronaries and carotids, while the association varied in strength and direction for SED and LIPA, respectively. If causal, clinical implications include avoiding high levels of daily SED and low levels of MVPA to reduce the risk of developing significant subclinical atherosclerosis.
Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023. Vol. 13, no 11, article id e073380
Keywords [en]
cardiovascular imaging, epidemiology, public health
National Category
Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:umu:diva-217547DOI: 10.1136/bmjopen-2023-073380ISI: 001181643400032PubMedID: 37996228Scopus ID: 2-s2.0-85177801853OAI: oai:DiVA.org:umu-217547DiVA, id: diva2:1818592
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaUniversity of GothenburgKarolinska InstituteRegion StockholmLinköpings universitetLund UniversityUmeå UniversityUppsala UniversityRegion Västra Götaland, ALFGBG- 720691Swedish Heart Lung Foundation, 201803792023-12-112023-12-112025-04-24Bibliographically approved