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Left ventricular hypertrophy: an ECG-based study of prevalence and risk factors in a multiethnic population
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Public Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland.
Department of Diabetes, Central Clinical School, Monash University, VIC, Melbourne, Australia.
Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
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2023 (English)In: Open heart, E-ISSN 2053-3624, Vol. 10, no 2, article id e002495Article in journal (Refereed) Published
Abstract [en]

Background: Left ventricular hypertrophy (LVH) is frequently seen in association with arterial hypertension and indicates poor prognosis. This study aimed to determine the prevalence of LVH and associated factors in a multiethnic population from Mauritius.

Methods: Population-based health surveys were performed in 2009 and 2015 and included in total 8961 individuals aged 35–75 years with recorded 12-lead ECG. LVH was defined according to three criteria: Sokolow-Lyon, Cornell voltage and Cornell product. Data were collected about health and lifestyle behaviour. Anthropometry and blood pressure were measured. Fasting levels of blood lipids and glucose were determined, oral glucose tolerance test was performed in people without glucose-lowering medications.

Results: The age-standardised prevalence of LVH was 9% (n=875) according to any of the three ECG criteria. Individuals with LVH were older, more likely to have hypertension, diabetes, known cardiovascular disease (CVD) and elevated levels of cholesterol and creatinine. Further, they were more likely to be of African descent (Creole) and have lower educational level. In a multivariable model, Creole (OR (95% CI)) (1.56 (1.33 to 1.83)), low educational level (1.49 (1.28 to 1.75)), hypertension (3.01 (2.55 to 3.56)), known CVD (1.42 (1.11 to 1.83)) and elevated creatinine (1.08 (1.03 to 1.14)) remained associated with LVH. Individuals with non-treated or uncontrolled hypertension had a higher risk for LVH (3.09 (95% CI 2.57 to 3.71) and 4.07 (95% CI 3.29 to 5.05), respectively), than individuals with well controlled hypertension or normotension.

Conclusion: LVH occurs more frequently in individuals with hypertension, as well as in individuals with African ancestry and/or low education level.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023. Vol. 10, no 2, article id e002495
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:umu:diva-217534DOI: 10.1136/openhrt-2023-002495ISI: 001102573300003PubMedID: 37935562Scopus ID: 2-s2.0-85177882151OAI: oai:DiVA.org:umu-217534DiVA, id: diva2:1819485
Funder
Umeå UniversityRegion Västerbotten, RV- 967561Swedish Heart Lung Foundation, 20130630Available from: 2023-12-14 Created: 2023-12-14 Last updated: 2025-02-10Bibliographically approved

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Taki, HinaSöderberg, StefanNilsson, Ulf

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