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METTL3 as a master regulator of translation in cancer: mechanisms and implications
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-8047-9298
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-2374-2045
2024 (English)In: NAR Cancer, E-ISSN 2632-8674, Vol. 6, no 1, article id zcae009Article in journal (Refereed) Published
Abstract [en]

Translational regulation is an important step in the control of gene expression. In cancer cells, the orchestration of both global control of protein synthesis and selective translation of specific mRNAs promote tumor cell survival, angiogenesis, transformation, invasion and metastasis. N6-methyladenosine (m6A), the most prevalent mRNA modification in higher eukaryotes, impacts protein translation. Over the past decade, the development of m6A mapping tools has facilitated comprehensive functional investigations, revealing the involvement of this chemical mark, together with its writer METTL3, in promoting the translation of both oncogenes and tumor suppressor transcripts, with the impact being context-dependent. This review aims to consolidate our current understanding of how m6A and METTL3 shape translation regulation in the realm of cancer biology. In addition, it delves into the role of cytoplasmic METTL3 in protein synthesis, operating independently of its catalytic activity. Ultimately, our goal is to provide critical insights into the interplay between m6A, METTL3 and translational regulation in cancer, offering a deeper comprehension of the mechanisms sustaining tumorigenesis.

Place, publisher, year, edition, pages
Oxford University Press, 2024. Vol. 6, no 1, article id zcae009
National Category
Biochemistry and Molecular Biology Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-222414DOI: 10.1093/narcan/zcae009PubMedID: 38444581Scopus ID: 2-s2.0-85187108906OAI: oai:DiVA.org:umu-222414DiVA, id: diva2:1846530
Funder
EU, Horizon 2020, 956810Swedish Research Council, 2022-01322Swedish Cancer Society, 22 2455 PjAvailable from: 2024-03-22 Created: 2024-03-22 Last updated: 2024-03-22Bibliographically approved

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Esteva-Socias, MargalidaAguilo, Francesca

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Esteva-Socias, MargalidaAguilo, Francesca
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Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Department of Molecular Biology (Faculty of Medicine)
Biochemistry and Molecular BiologyCancer and Oncology

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