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Comparative label-free proteomics of the neonatal meningitis-causing Escherichia coli K1 IHE3034 and RS218 morphotypes
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0003-3318-9084
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
2024 (English)In: Microbiology Resource Announcements, E-ISSN 2576-098X, Vol. 13, no 2, article id e00960-23Article in journal (Refereed) Published
Abstract [en]

The proteome of two newborn meningitis Escherichia coli K1 (NMEC) morphotypes was examined via a label-free proteomics approach. Besides shared NMEC virulence factors, the two strains have different evolutionary strategies-strain IHE3034 tends to perform anaerobic respiration continuously, while strain RS218 maintains its filamentous morphotype due to active SOS response.
Place, publisher, year, edition, pages
American Society for Microbiology, 2024. Vol. 13, no 2, article id e00960-23
Keywords [en]
ExPEC, newborn meningitis, NMEC, proteomics
National Category
Microbiology Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-222287DOI: 10.1128/mra.00960-23ISI: 001153943500006PubMedID: 38289054Scopus ID: 2-s2.0-85186460566OAI: oai:DiVA.org:umu-222287DiVA, id: diva2:1846659
Funder
Swedish Research Council, 2019-01720The Kempe Foundations, SMK-1961Available from: 2024-03-25 Created: 2024-03-25 Last updated: 2024-03-25Bibliographically approved

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Zlatkov, Nikola

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