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Long-term follow-up of bone density changes in total hip arthroplasty: comparative analysis from a randomized controlled trial of a porous titanium construct shell vs. a porous coated shell.
Division of Orthopaedics, Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Danderyd, Stockholm, Sweden.
Division of Orthopaedics, Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Danderyd, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.ORCID iD: 0000-0002-5469-2730
Division of Orthopaedics, Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Danderyd, Stockholm, Sweden.
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2024 (English)In: International Orthopaedics, ISSN 0341-2695, E-ISSN 1432-5195, Vol. 48, p. 2835-2842Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Periacetabular bone loss poses a considerable challenge in the longevity and stability of acetabular implants used in total hip arthroplasty (THA). Innovations in implant design, specifically the introduction of three-dimensional (3D) porous titanium constructs, might reduce bone resorption. The purpose of this study was to build upon our previous randomized controlled trial, which found no change in periacetabular bone loss between a 3D porous none-hydroxyapatite coated titanium cup and a standard porous hydroxyapatite coated cup over a two year follow-up period by extending the follow-up duration to ten years post-surgery.

METHODS: This was a single-centre, long-term follow-up study conducted over a ten year period in patients who had previously participated in a randomized controlled trial comparing a 3D porous titanium construct shell (PTC group) with a standard porous hydroxyapatite coated titanium shell (PC-group). The primary outcome measured was the change in bone mineral density (BMD) within four specific periacetabular zones, alongside overall bone loss, which was assessed through BMD in the lumbar spine at two, six and ten years postoperatively. Secondary outcomes included clinical outcome measures.

RESULTS: In total, 18 in the PTC and 20 in the PC group were analysed for the primary endpoint up to ten years. The mean bone mineral density in zones 1-4 was 3.7% higher in the PTC group than in the PC group at six years postoperatively and 12.0% higher at ten years. Clinical outcomes, and the frequency of adverse events did not differ between the groups.

CONCLUSIONS: The PTC group displayed superior long-term bone preservation compared to the PC group while maintaining similar clinical outcomes up to ten years postoperatively. Although with a small sample size, our findings suggest that porous titanium cups have the potential to minimize BMD loss around the cup which could contribute to improving THA outcomes and implant durability.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 48, p. 2835-2842
Keywords [en]
Bone mineral density, Implant material selection, Long-term follow-up, Periacetabular bone loss, Porous titanium cup, THA
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:umu:diva-229490DOI: 10.1007/s00264-024-06289-zISI: 001306758400001PubMedID: 39243289Scopus ID: 2-s2.0-85203241391OAI: oai:DiVA.org:umu-229490DiVA, id: diva2:1896735
Available from: 2024-09-11 Created: 2024-09-11 Last updated: 2025-04-24Bibliographically approved

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