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Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants
Umeå University, Faculty of Science and Technology, Chemistry.
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2008 (English)In: Ecotoxicology and Environmental Safety, ISSN 1090-2414, Vol. 71, no 2, 319-27 p.Article in journal (Refereed) Published
Abstract [en]

Proteomic effect screening in zebrafish liver was performed to generate hypotheses following exposure (21 days) to a structurally diverse mixture of brominated flame retardants (BFRs). Fish were exposed to two doses (10 and 100 nmol/g feed). Two-dimensional gel-electrophoresis, image analysis and MALDI-TOF mass-spectrometry revealed 13 and 19 significant responses in males and females, respectively. Effects on proteins related to cellular maintenance and stress were observed in both genders. Regulated proteins were gender-specific, but functionally indicated common protective responses (peroxiredoxin 6 and Zgc:92891 in males and transketolase in females) suggesting oxidative stress. Betaine homocysteine methyltransferase (BHMT) was induced in both genders. In addition a female-specific downregulation of ironhomeostatic proteins (iron-regulatory protein 1 and transferrin) were observed. Our proteomic approach revealed novel responses that suggest important gender-specific sensitivity to BFRs that should be considered when interpreting adverse effects of BFRs.

Place, publisher, year, edition, pages
Elsevier Inc , 2008. Vol. 71, no 2, 319-27 p.
Keyword [en]
Fish, Proteomics, BFR, MALDI-TOF
URN: urn:nbn:se:umu:diva-18998DOI: 10.1016/j.ecoenv.2007.12.010PubMedID: 18258299OAI: diva2:201133
Available from: 2009-03-03 Created: 2009-03-03 Last updated: 2010-01-19Bibliographically approved

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